Table 4. Frequency of micronuclei after treatment with andiroba oil.
Andiroba oil (mg/kg/day) | ||||
---|---|---|---|---|
Parameter | Negative control | 500 | 1000 | 2000 |
MN-PCE (number) | 1.66 ± 2.42 | 2 ± 2.09 | 1.16 ± 1.60 | 2.5 ± 1.22 |
MN-PCE (%) | 8.33 ± 12.11 | 10.00 ± 10.49 | 5.83 ± 8.01 | 12.50 ± 6.12 |
PCE/NCE ratio | 1.77 ± 0.57 | 2.39 ± 0.60 | 2.10 ± 0.63 | 2.29 ± 0.42 |
MN – micronuclei, NCE – normochromatic erythrocytes, PCE – polychromatic erythrocytes. The values represent the mean ± SD and were analyzed by ANOVA. There were no significant differences between the responses to andiroba oil and the negative control, or among the doses of oil tested.