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. 2016 Apr 29;7(8):900–909. doi: 10.7150/jca.14506

Figure 2.

Figure 2

Platinum induces less p53 in 3D architecture (western blot). (A) L-OHP induced p53 in a dose-dependent manner. (B) CDDP induced p53 in a time-dependent manner. (C-D) CDDP induced less p53 in 3D cultures than in the respective 2D cultures. Relative quantities of p53 were normalized to β-actin and diagramed, respectively (right). (E) CDDP induced similar γ-H2A.X protein in HCT116 3D cultures as in 2D cultures. Relative quantities of p53 were normalized to α-tubulin and diagrammed (right).