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Platinum activates p38 and ERK1/2 (western blot). CDDP activated MAPKs (p38, ERK) in a time-dependent manner in HCT116 3D cultures (A) and LoVo 3D cultures (C). L-OHP activated MAPKs (p38, ERK) in a dose-dependent manner in HCT116 3D cultures (B) and LoVo 3D cultures (D).
