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. 2016 Apr 29;7(8):900–909. doi: 10.7150/jca.14506

Figure 6.

Figure 6

MAPKs (p38 and ERK1/2) do not contribute to the 3D architecture-mediated p53-dependent decrease in chemosensitivity. (western blot). (A) Cells were treated with vehicle or SB202190 1 hour prior to CDDP treatment. CDDP's activation of p38 was remarkably inhibited by SB202190. Inhibition of p38 activation decreased CDDP's induction of p53. (B) There was no detectable difference in p-p38 between 2D cultures and 3D cultures. (C) Cells were treated with vehicle or U0126 1 hour prior to CDDP treatment. CDDP's activation of ERK was remarkably inhibited by U0126. Inhibition of ERK activation did not detectably change CDDP's induction of p53.