Table 1.
Characteristics of enrolled mCRC patients.
| Variables | Total | N | (%) |
|---|---|---|---|
| Clinicopathological factors | |||
| Age (years) | <65 / ≥65 | 82 / 38 | 68.3 / 31.7 |
| Sex | Male / Female | 59 / 61 | 49.2 / 50.8 |
| ECOG-PS | 0 / 1 / 2 / 3 / 4 | 1 / 70 / 37 / 9 /3 | 0.8 / 58.3 / 30.8 / 7.5 /2.5 |
| Tumor Site | Colon / Rectum | 88 / 32 | 73.3 / 26.7 |
| BMI (kg/m2) | <18.5 / 18.5-22.9 / ≥23 | 16 / 54 / 48 a | 13.3 / 45.0 / 40.0 |
| Liver Metastasis | No / Yes | 45 / 75 | 37.5 / 62.5 |
| Prior Surgery | No / Yes | 23 / 97 | 19.2 / 80.8 |
| Prior Chemotherapy | None / 1st line / 2nd line / ≥3rd line | 15 / 16 / 34 /55 | 12.5 / 13.3 / 28.3 / 45.8 |
| Prior Radiotherapy | No / Yes | 87 / 33 | 72.5 / 27.5 |
| Laboratory factors | |||
| CEA (ng/mL) | ≤5 / >5 | 22 / 95 b | 18.3 / 79.2 |
| CA19-9 (U/mL) | ≤27 / >27 | 40 / 57 c | 41.2 / 58.8 |
| Hb (g/dL) | <12 / ≥12 | 59 / 61 | 49.2 / 50.8 |
| Albumin (g/dL) | <3.5 / ≥3.5 | 12 / 108 | 10.0 / 90.0 |
| CRP (mg/L) | <10.0 / ≥10.0 | 75 / 45 | 62.5 / 37.5 |
| PLT (× 103/μL) | <400 / ≥400 | 110 / 10 | 91.7 / 8.3 |
| Ferritin | <150 / ≥150 | 79 / 41 | 65.8 / 34.2 |
| WBC (× 103/μL) | <10.0 / ≥10.0 | 109 / 11 | 90.8 / 9.2 |
| ANC (cells/μL) | ≤4336.0 / >4336.0 | 60 / 60 | 50.0 / 50.0 |
| ALC (cells/μL) | ≤1291.1 / >1291.1 | 60 / 60 | 50.0 / 50.0 |
| AMC (cells/μL) | ≤413.3 / >413.3 | 47 / 73 | 39.2 / 60.8 |
a 118 total patients measured, b 117 patients examined, c 97 patients examined.
ECOG-PS = Eastern Cooperative Oncology Group performance status; BMI = body mass index; CEA = carcinoembryonic antigen; CA19-9 = carbohydrate antigen 19-9; Hb = hemoglobin; CRP = C-reactive protein; PLT = platelets; WBC = white blood cell; ANC = absolute neutrophil count; ALC = absolute lymphocyte count; AMC = absolute monocyte count.