Table 5.
Subgroup characteristics according to serum ferritin.
| Variable | Ferritin <150 (ng/mL) | Ferritin ≥150 (ng/mL) | p-value | |
|---|---|---|---|---|
| 79 | 41 | |||
| Clinicopathological factors | ||||
| ECOG-PS | 0 / 1 / 2 / 3 /4 | 1 / 54 / 19 / 4 / 1 | 0 / 16 / 18 / 5 / 2 | 0.025 |
| BMI (kg/m2) | <18.5 / 18.5-22.9 / ≥23 | 11 / 34 / 33 a | 5 / 20 /15 b | 0.803 |
| Liver Metastasis | No / Yes | 33 / 46 | 12 / 29 | 0.180 |
| Prior Surgery | No / Yes | 17 / 62 | 6 / 35 | 0.363 |
| Prior Chemotherapy | None / 1st line / 2nd line / ≥3rd line | 14 / 10 / 21 / 34 | 1 / 6 / 13 / 21 | 0.124 |
| Prior Radiotherapy | No / Yes | 58 / 21 | 29 / 12 | 0.755 |
| Laboratory factors | ||||
| CEA (ng/mL) | ≤5 / >5 | 15 / 61 c | 7 / 34 | 0.725 |
| CA19-9 (U/mL) | ≤27 / >27 | 27 / 40 d | 13 / 17 e | 0.779 |
| Hb (g/dL) | <12 / ≥12 | 39 / 40 | 20 / 21 | 0.951 |
| Albumin (g/dL) | <3.5 / ≥3.5 | 5 / 74 | 7 / 34 | 0.063 |
| CRP (mg/L) | <10.0 / ≥10.0 | 59 / 20 | 16 / 25 | 0.000 |
| PLT (× 103/μL) | <400 / ≥400 | 73 / 6 | 37 / 4 | 0.685 |
| WBC (× 103/μL) | <10.0 / ≥10.0 | 75 / 4 | 34 / 7 | 0.031 |
| ANC (cells/μL) | ≤4336.0 / >4336.0 | 44 / 35 | 16 / 25 | 0.083 |
| ALC (cells/μL) | ≤1291.1 / >1291.1 | 35 / 44 | 25 / 16 | 0.083 |
| AMC (cells/μL) | ≤413.3 / >413.3 | 39 / 40 | 8 / 33 | 0.001 |
a 78 patients, b 40 patients, c 76 patients, d 67 patients, e 30 patients were assessed.
ECOG-PS = Eastern Cooperative Oncology Group performance status; BMI = body mass index; CEA = carcinoembryonic antigen; CA19-9 = carbohydrate antigen 19-9; Hb = hemoglobin; CRP = C-reactive protein; PLT = platelets; WBC = white blood cell; ANC = absolute neutrophil count; ALC = absolute lymphocyte count; AMC = absolute monocyte count.