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Work pattern of LncRNA-miRNA crosstalk. A. LncRNA acts as a ceRNA. By working as a sponge, lncRNA traps miRNA and inhibits miRNA's repression effect; B. LncRNA acts as the host gene of miRNA. MiRNA is encoded by lncRNA and alternations on lncRNA expression will concomitantly influence miRNA transcription; C. LncRNA targets the promoter of miRNA. HULC guides DNMT1 to the promoter of miRNA thus inducing methylation of CpG islands in the miRNA promoter.
