Table 1.
Pathological changes in various mice after azoxymethane/dextran sulfate sodium treatment
| Ingested DSS concentration | Body weight loss (> 20%) | Granulocyte infiltration (> 400/field) | Fibroblast accumulation (> 20% type I collagen+ areas) | Tumor numbers | |
| Wild-type mice | 3.0% | + | + | + | > 20 |
| CCR1-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | + | > 20 | |
| CCR5-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | - | < 7 | |
| CCL3-deficient mice | 3.0% | - | - | - | < 5 |
| 4.5% | + | + | - | < 5 |
Table is prepared according to Sasaki et al[22]. DSS: Dextran sulfate sodium.