Table 2.
Hazard ratios and 95% confidence intervals for the association between potential prognosis factors and gastric cancer
| Characteristic | n |
DFS |
OS |
||||||
| HR (95%CI)1 | P value1 | HR (95%CI)2 | P value2 | HR (95%CI)1 | P value1 | HR (95%CI)2 | P value2 | ||
| Age | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||
| < 60 yr | 792 | 1 | 1 | 1 | 1 | ||||
| ≥ 60 yr | 772 | 1.58 (1.35-1.85) | 1.42 (1.18-1.71) | 1.60 (1.35-1.89) | 1.39 (1.15-1.70) | ||||
| Gender | 0.674 | 0.992 | 0.976 | 0.651 | |||||
| Female | 387 | 1 | 1 | 1 | 1 | ||||
| Male | 1177 | 0.96 (0.80-1.15) | 1.00 (0.82-1.23) | 1.00 (0.82-1.21) | 1.05 (0.85-1.30) | ||||
| Minority | 0.364 | 0.600 | 0.563 | 0.797 | |||||
| Han population | 1507 | 1 | 1 | 1 | 1 | ||||
| Others | 57 | 0.81 (0.51-1.28) | 0.87 (0.52-1.46) | 0.87 (0.54-1.40) | 0.93 (0.55-1.59) | ||||
| History of familial cancer | 0.367 | 0.295 | 0.610 | 0.523 | |||||
| No | 1157 | 1 | 1 | 1 | 1 | ||||
| Yes | 157 | 1.12 (0.87-1.44) | 1.15 (0.89-1.48) | 1.07 (0.82-1.41) | 1.09 (0.83-1.44) | ||||
| Tumor location | < 0.001 | 0.743 | 0.003 | 0.545 | |||||
| Cardia | 1007 | 1 | 1 | 1 | 1 | ||||
| Non-cardia | 557 | 1.34 (1.14-1.57) | 0.97 (0.81-1.16) | 1.29 (1.09-1.53) | 0.94 (0.78-1.14) | ||||
| TNM stage | |||||||||
| I | 376 | 1 | 1 | 1 | |||||
| II | 329 | 2.71 (1.92-3.83) | < 0.001 | 2.61 (1.76-3.87) | < 0.001 | 3.27 (2.21-4.83) | < 0.001 | 3.33 (2.14-5.18) | < 0.001 |
| III | 859 | 6.25 (4.64-8.44) | < 0.001 | 6.50 (4.57-9.23) | < 0.001 | 7.58 (5.37-10.70) | < 0.001 | 8.70 (5.83-12.98) | < 0.001 |
| Tumor embolus | < 0.001 | 0.339 | < 0.001 | 0.802 | |||||
| No | 1175 | 1 | 1 | 1 | 1 | ||||
| Yes | 289 | 1.81 (1.53-2.13) | 1.10 (0.90-1.34) | 1.70 (1.43-2.03) | 0.97 (0.79-1.20) | ||||
| Neural invasion | < 0.001 | < 0.001 | < 0.001 | < 0.001 | |||||
| No | 1334 | 1 | 1 | 1 | 1 | ||||
| Yes | 230 | 1.90 (1.57-2.30) | 1.51 (1.21-1.89) | 2.06 (1.69-2.52) | 1.68 (1.33-2.12) | ||||
| Adjuvant chemotherapy | 0.008 | 0.0151 | 0.052 | 0.002 | |||||
| No | 678 | 1 | 1 | 1 | 1 | ||||
| Yes | 886 | 1.24 (1.06-1.47) | 0.79 (0.65-0.95) | 1.19 (1.00-1.40) | 0.73 (0.60-0.90) | ||||
| Adjuvant radiotherapy | 0.008 | 0.478 | 0.254 | 0.667 | |||||
| No | 1462 | 1 | 1 | 1 | 1 | ||||
| Yes | 102 | 1.46 (1.10-1.93) | 1.11 (0.83-1.49) | 1.20 (0.88-1.64) | 0.93 (0.67-1.29) | ||||
| HER2 | 0.561 | 0.105 | 0.898 | 0.118 | |||||
| Negative (-) | 1015 | 1 | 1 | 1 | 1 | ||||
| Positive (+) | 549 | 0.95 (0.81-1.12) | 1.19 (0.96-1.46) | 0.99 (0.83-1.18) | 1.19 (0.96-1.48) | ||||
1
HRs and 95%CI with P value based on Cox proportional hazard regression model;
2
Multivariable HRs and 95%CI with P value based on Cox proportional hazard regression model. Number of observations in the original data set = 1562. Number of observations used = 1313, owing to the missing value occurring in family history of cancer (249). DFS: Disease free survival; OS: Overall survival.