TABLE III.

Comparison of co-morbid conditions between women with endometriosis from the United States (EA) and Puerto Rico (ERP)

Conditions	EA N = 4,358a n (%)	ERP N = 878a n (%)	p-valueb
Allergic conditions
Allergies*	2,853 (65.5)	158 (23.8)	<0.001
Asthma*	631 (14.5)	122 (18.4)	0.010
Autoimmunity
Lupus	34 (0.8)	6 (0.9)	0.646
Sjögren’s syndrome	23 (0.5)	1 (0.2)	0.358
Rheumatoid arthritis	83 (1.9)	11 (1.7)	0.760
Multiple sclerosis (MS)	22 (0.5)	4 (0.6)	0.770
Endocrine disorders
Hypoglycemia	349 (8.1)	45 (6.8)	0.279
Hyperthyroidism	66 (1.5)	5 (0.8)	0.157
Diabetes	62 (1.4)	15 (2.3)	0.126
Thyroiditis	75 (1.7)	17 (2.6)	0.161c
Hyperprolactinemia*	125 (2.9)	5 (0.8)	<0.001
Hypothyroidism	290 (6.7)	32 (4.8)	0.074
Cancer
Breast cancer	16 (0.4)	2 (0.3)	>0.999
Ovarian cancer	10 (0.2)	1 (0.2)	>0.999
Others
Fibromyalgia*	272 (6.3)	14 (2.1)	<0.001
Mitral valve prolapse (MVP)*	636 (18.4)	37 (5.6)	<0.001
Chronic fatigue syndrome (CFS)*	197 (4.6)	7 (1.1)	<0.001

^*statistically significant.

^aPercents are based on total number of women per group who responded to each question (excludes blank or non-applicable responses) and may not equal the listed denominator per group.

^bP-values are from crude comparisons using contingency tables; in addition, all comparisons were further adjusted for pertinent covariates, such as each of age at surgical diagnosis, time to diagnosis from onset of symptoms, duration of living with endometriosis, and calendar timing of diagnosis as they were statistically significantly different between groups and may impact findings. Fibromyalgia was additionally adjusted for current age when adjusting for calendar timing of diagnosis due to its differential on the observed range of calendar timing of diagnosis. Any changes in conclusions as a result of the adjustments are indicated.

^cStatistically significant (p = 0.002) when adjusted for calendar timing of diagnosis.