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. 2015 Oct 29;5(5):e1108513. doi: 10.1080/2162402X.2015.1108513

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Abcc3 is responsible for NK cell chemo-resistance. (A and B) Relative expression of Abca6 and Abcc3 transporters in blood NK cells at 72 h, **p < 0.001. (C and D) Time course of Abca6 and Abcc3 expression in PBLs from naïve mice (n = 20) treated in vitro with 1 μM TMZ or DMSO; *p = 0.01, **p < 0.005 and ***p < 0.0001. (E and F) Abcc3 levels in NK and CD8⁺ T cells from glioma-bearing mice (n = 5/group) after three treatments of TMZ (red line) or DMSO (green line). (G and H) multidrug-resistance activity assay in NK and CD8⁺ T cells from PBLs of naive mice (n = 25) treated in vitro with 1 μM TMZ or DMSO for 4 h. MAF values > 25 are indicative of multidrug-resistant phenotype.