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. 2015 Oct 29;5(5):e1108513. doi: 10.1080/2162402X.2015.1108513

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 5. — Cytotoxicity of glioma-infiltrating NK cells is promoted by TMZ treatment. (A) IFNγ production in blood NK cells (n = 4/group); p < 0.005. (B) Cytotoxic specificity of peripheral NK cells from naïve mice, TMZ- and vehicle-treated glioma-bearing mice (n = 10/group) against GL261 cells in vitro. Effector:target ratio (E:T) 10:1, 20:1, 40:1. p < 0.001. (C and D) Relative expression of Prf1, GzmB and IFNγ in TILs at early (C) and later time point (D). *p < 0.01; **p < 0.001; ***p < 0.0001.