Table 3.

Relationship between clinicopathological factors and autoantibodies against MDM2 and c-Myc in lung cancer patients.

		anti-MDM2		anti-c-Myc
		Mean ± SD	p	Mean ± SD	p
Mean age ± SD	66.0±9.9
Age range	45-86
	21	0.0641 ± 0.0600		0.1434 ± 0.1079
≥65	29	0.0448 ± 0.0400	0.178	0.2643 ± 0.5240	0.305
Gender
Male	28	0.0544 ± 0.0608		0.2195 ± 0.5155
Female	22	0.0510 ± 0.0320	0.812	0.2059 ± 0.2097	0.908
TMN stages
1 (IA+ IB)	29	0.0525 ± 0.0448		0.2656 ± 0.5214
2 (≥II A)	21	0.0536 ± 0.0570	0.939	0.1416 ± 0.1230	0.292
Depth of tumor invasion
1(T1)	15	0.0687 ± 0.0752		0.1522 ± 0.1249
2(≥T2)	35	0.0462 ± 0.0329	0.282	0.2398 ± 0.4790	0.491
Lymph node Metastasis
Negative	34	0.0493 ± 0.0427	0.460	0.2527 ± 0.4856	0.326
Positive	16	0.0606 ± 0.0632		0.1303 ± 0.1022
Histological grade
I	13	0.0457 ± 0.0455		0.1263 ± 0.1200
II	19	0.0447 ± 0.0255	0.342	0.1651 ± 0.1948	0.326
III	18	0.0668 ± 0.0683		0.3276 ± 0.6356
Histology
Adenocarcinoma	26	0.0468 ± 0.0398		0.1633 ± 0.1779
Squamous cell	16	0.0587 ± 0.0622		0.2963+0.6777
carcinoma
Others	8	0.0614 ± 0.0554	0.663	0.2111 ± 0.1873	0.598
Post-op chemo
None	33	0.0487 ± 0.0439		0.2439 ± 0.4938
yes	17	0.0612 ± 0.0602	0.407	0.1545 ± 0.1139	0.467
Tumor size
< 4cm	21	0.0563 ± 0.0661		0.1395 ± 0.1071
≥4cm	29	0.0505 ± 0.0346	0.719	0.2670 ± 0.5235	0.278
Chest wall/Mediastinal invasion
None	45	0.0520 ± 0.0517		0.1544 ± 0.1526
yes	5	0.0615 ± 0.0286	0.689	0.7453 ± 1.1732	0.323
Metastasis
None	36	0.0612 ± 0.0546		0.2326 ± 0.4703
Yes	14	0.0317 ± 0.0250	0.059	0.1642 ± 0.1541	0.598
History of Malignancies
None	34	0.0629 ± 0.0569	0.005*	0.2483 ± 0.4864	0.382
Yes	16	0.0318 ± 0.0165		0.1393 ± 0.1042

^*p < 0.05

^**p < 0.01 (t-test or One-way ANOVA)