Figure 3.

Recruitment of blood leukocytes into established peritoneal carcinomatosis lesions. 7 Tesla, T2*-weighted, MR images of abdomen of a representative mouse from tumor-bearing mice injected with syngeneic leukocytes labeled with SPIO particles (0.22 mg Fe/mL), at different time points (basal, 3 h, 24 h, panel A). At 24 h, the peripheral darkening of peritoneal lesions is strongly evident, without changes in signal intensity of the paravertebral muscle (negative control). A slight reduction of T2* relaxation time is detectable 3 h after SPIO-labeled leukocyte injection, which becomes stronger 24 h after injection (B, C). ROI based analysis of T2-maps: white color, skeletal muscle; black color, peritoneal lesions.