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. 2016 Feb 18;5(5):e1137417. doi: 10.1080/2162402X.2015.1137417

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — Evaluation the influence of thymic hyperplasia (TH) on the recovery of CD4⁺ T cell subsets after chemotherapy. Numbers of naive CD4⁺T cells (A) and natural CD4⁺ regulatory T cells (nTreg) (B) in peripheral blood were measured serially before (baseline) and after (0, 3, 6, 9, 12 mo post-chemotherapy) treatment in 20 patients with TH (•) and 18 patients without TH (▪) following chemotherapy. The presence of TH was found to influence the repopulation of naïve CD4⁺ T cells and nTregs after chemotherapy (p = 0.042, 0.038), and earlier recovery of naïve CD4⁺ T cells and nTregs was found in subjects with TH after chemotherapy. Data are shown as mean ± SD. p values were assessed by general linear model analysis for repeated measure data.^★p < 0.05, compared with the nadir at the end of therapy in the same group.