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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Mamm Genome. 2008 Sep 3;19(9):623–633. doi: 10.1007/s00335-008-9138-5

Figure 2. A splice site mutation that changes the invariant T in the splice donor to an A was identified in intron 1 of the Prph2 gene.

Figure 2

Panels A–C show sequence chromatograms from wild-type, heterozygous and homozygous mutant DNA, respectively. The mutant causes the use of a cryptic splice site downstream (panel D) and incorporates 25 extra base pairs into the mRNA, this is not detected in wild-type C57BL6/J mice (panel E).