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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Mamm Genome. 2008 Sep 3;19(9):623–633. doi: 10.1007/s00335-008-9138-5

Figure 4. The mutation causes a frameshift and a nonsense codon that truncates the protein (panel A).

Figure 4

Shaded areas indicate the region of the protein that is equivalent to wild-type, the red underlined sequence indicates the tetraspanin domain. Western blot analysis (panel B) shows the reduction of wild-type protein in the heterozygous mutant (+/−) and its absence in the homozygous mutant (−/−), β-actin is shown as a loading control.