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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Mamm Genome. 2008 Sep 3;19(9):623–633. doi: 10.1007/s00335-008-9138-5

Figure 6. Histological analysis shows degeneration of the photoreceptors in mutant mice.

Figure 6

Wild-type, heterozygous and homozygous mutant retinas are shown at the indicated time-points. Note the shortened outer segments (OS) in the mutants (arrow). Displaced nuclei are frequently seen in the OS of heterozygous mutants at 6 and 10 months (arrowhead). A marked reduction of the outer nuclear layer (ONL) in the heterozygote and its absence in the homozygous mutants is observed at 10 months. Scale bar indicates 100mm.