Table 3. Peak values from opioid agonist scale, street value and cognitive measures.
| Drug condition (mg, p.o.) | ||||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| Placebo | Oxycodone | Dronabinol | ||||||
|
|
|
|||||||
| F (6, 63) | 30 | 60 | 5 | 10 | 20 | 30 | ||
| Maximum values | ||||||||
| Opioid agonist adjective scale | ||||||||
| Participant-rated total score | 6.3 | 4.8 (0.7) | 9.5 (1.2) | 13.5 (2.0) | 6.9 (1.4) | 5.2 (1.2) | 8.8 (1.8) | 9.1 (2.8) |
| Coasting/spaced out | 3.3 | 0.1 (0.1) | 0.2 (0.1) | 0.4 (0.2) | 0.8 (0.4) | 0.8 (0.3) | 1.2 (0.3) | 1.1 (0.4) |
| Dry mouth | 3.3 | 0.7 (0.2) | 1.1 (0.3) | 1.4 (0.3) | 0.9 (0.3) | 1.0 (0.2) | 1.3 (0.3) | 1.8 (0.3) |
| Drunken | 3.5 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.5 (0.3) | 0.8 (0.5) |
| Observer-rated total score | 9.4 | 1.8 (0.5) | 4.8 (0.7) | 7.9 (0.7) | 3.8 (0.9) | 2.8 (0.5) | 3.9 (0.6) | 4.2 (1.1) |
| Coasting | 4.9 | 0.1 (0.1) | 0.2 (0.1) | 0.5 (0.2) | 0.4 (0.2) | 0.3 (0.1) | 1.0 (0.2) | 0.8 (0.2) |
| Good mood | 14.9 | 0.1 (0.1) | 0.9 (0.2) | 1.6 (0.1) | 0.2 (0.1) | 0.4 (0.1) | 0.5 (0.2) | 0.7 (0.2) |
| Street value | 17.3 | 2.5 (1.4) | 15.4 (2.9) | 20.8 (2.9) | 2.3 (1.0) | 1.5 (0.9) | 7.9 (3.3) | 6.1 (2.2) |
| Continuous performance task | ||||||||
| Incorrect responses | 2.9 | 13.5 (2.7) | 15.8 (3.2) | 14.8 (4.1) | 30.3 (11.0) | 17.3 (3.5) | 15.8 (3.2) | 22.1 (6.1) |
| Reaction time for hits | 2.4 | 365.5 (7.7) | 375.8 (11.4) | 366.8 (8.6) | 374.8 (7.5) | 379.2 (9.8) | 381.8 (10.4) | 390.2 (9.8) |
| Reaction time for false hits | 2.5 | 264.5 (15.7) | 279.0 (18.2) | 252.2 (7.7) | 226.7 (19.5) | 220.3 (13.9) | 256.9 (17.3) | 284.8 (27.0) |
| Minimum values | ||||||||
| Time estimation - 80 seconds | 3.5 | 48.7 (6.3) | 50.4 (6.5) | 45.1 (7.5) | 41.6 (6.7) | 43.2 (7.0) | 38.5 (6.9) | 21.5 (6.7) |
| Continuous performance task | ||||||||
| Correct misses | 2.8 | 260.3 (2.5) | 256.3 (2.8) | 258.1 (3.5) | 243.0 (10.3) | 257.0 (3.3) | 256.0 (3.6) | 249.4 (5.8) |
Bolded F values indicate p<0.05. Bold mean (SE) values indicate significant (p<0.05) post-hoc compared to placebo. Only individual adjective items with significant post-hoc results are shown. Only cognitive test outcomes with significant dose effects are shown. For each drug condition, n=12 except n=9 for dronabinol 30mg. P.O. indicates oral route.