Table 4. Maximum withdrawal suppression values.
| Drug condition (mg, p.o.) | ||||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| Placebo | Oxycodone | Dronabinol | ||||||
|
|
|
|||||||
| F (6, 63) | 30 | 60 | 5 | 10 | 20 | 30 | ||
| Participant- rated measures: | ||||||||
| Opioid antagonist adjectives total | 8.1 | 13.1 (2.2) | 4.7 (1.7) | 3.8 (1.3) | 9.5 (2.1) | 12.3 (2.3) | 7.5 (2.0) | 6.8 (1.9) |
| Backache | 4.4 | 1.1 (0.3) | 0.5 (0.2) | 0.4 (0.2) | 1.1 (0.3) | 1.3 (0.4) | 0.7 (0.2) | 0.4 (0.2) |
| SOWS total | 10.5 | 7.3 (1.2) | 2.8 (1.2) | 2.0 (1.1) | 5.3 (1.3) | 6.8 (1.5) | 4.8 (1.5) | 3.8 (1.7) |
| Feeling sick | 4.4 | 1.1 (0.3) | 0.3 (0.2) | 0.2 (0.2) | 0.8 (0.3) | 0.8 (0.3) | 0.5 (0.2) | 0.3 (0.2) |
| Muscular tension | 4.9 | 0.8 (0.3) | 0.3 (0.2) | 0.2 (0.2) | 0.7 (0.2) | 0.8 (0.3) | 0.3 (0.2) | 0.4 (0.2) |
| Runny eyes | 3.1 | 0.7 (0.3) | 0.1 (0.1) | 0.1 (0.1) | 0.2 (0.1) | 0.3 (0.1) | 0.3 (0.1) | 0.1 (0.1) |
| VAS opioid withdrawal severity | 10.2 | 64.4 (8.6) | 21.6 (10.2) | 11.1 (6.1) | 52.3 (10.3) | 55.9 (10.2) | 36.3 (11.0) | 36.6 (11.8) |
| Observer-rated measures: | ||||||||
| Opioid antagonist adjectives total | 6.9 | 4.4 (1.0) | 0.5 (0.2) | 0.3 (0.1) | 2.2 (0.8) | 3.2 (0.9) | 2.0 (0.6) | 1.3 (0.6) |
| Yawning | 4.4 | 0.6 (0.1) | 0.0 (0.0) | 0.0 (0.0) | 0.3 (0.1) | 0.3 (0.1) | 0.2 (0.1) | 0.1 (0.1) |
| Watery eyes | 4.0 | 0.3 (0.1) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.3 (0.1) | 0.0 (0.0) | 0.0 (0.0) |
| OOWS total | 12.7 | 2.8 (0.4) | 0.9 (0.2) | 0.0 (0.0) | 1.8 (0.4) | 2.4 (0.4) | 2.0 (0.2) | 1.1 (0.2) |
| Rhinorhea | 3.2 | 0.4 (0.1) | 0.0 (0.0) | 0.0 (0.0) | 0.2 (0.1) | 0.1 (0.1) | 0.3 (0.1) | 0.0 (0.0) |
Bolded F values indicate p<0.05. Bold mean (SE) values indicate significant (p<0.05) post-hoc compared to placebo. Only individual items with significant post-hoc result for dronabinol are shown. P.O. indicates oral route.