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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Drug Alcohol Depend. 2016 May 10;164:143–150. doi: 10.1016/j.drugalcdep.2016.05.002

Table 4. Maximum withdrawal suppression values.

Drug condition (mg, p.o.)

Placebo Oxycodone Dronabinol


F (6, 63) 30 60 5 10 20 30
Participant- rated measures:
Opioid antagonist adjectives total 8.1 13.1 (2.2) 4.7 (1.7) 3.8 (1.3) 9.5 (2.1) 12.3 (2.3) 7.5 (2.0) 6.8 (1.9)
 Backache 4.4 1.1 (0.3) 0.5 (0.2) 0.4 (0.2) 1.1 (0.3) 1.3 (0.4) 0.7 (0.2) 0.4 (0.2)
SOWS total 10.5 7.3 (1.2) 2.8 (1.2) 2.0 (1.1) 5.3 (1.3) 6.8 (1.5) 4.8 (1.5) 3.8 (1.7)
 Feeling sick 4.4 1.1 (0.3) 0.3 (0.2) 0.2 (0.2) 0.8 (0.3) 0.8 (0.3) 0.5 (0.2) 0.3 (0.2)
 Muscular tension 4.9 0.8 (0.3) 0.3 (0.2) 0.2 (0.2) 0.7 (0.2) 0.8 (0.3) 0.3 (0.2) 0.4 (0.2)
 Runny eyes 3.1 0.7 (0.3) 0.1 (0.1) 0.1 (0.1) 0.2 (0.1) 0.3 (0.1) 0.3 (0.1) 0.1 (0.1)
VAS opioid withdrawal severity 10.2 64.4 (8.6) 21.6 (10.2) 11.1 (6.1) 52.3 (10.3) 55.9 (10.2) 36.3 (11.0) 36.6 (11.8)
Observer-rated measures:
Opioid antagonist adjectives total 6.9 4.4 (1.0) 0.5 (0.2) 0.3 (0.1) 2.2 (0.8) 3.2 (0.9) 2.0 (0.6) 1.3 (0.6)
 Yawning 4.4 0.6 (0.1) 0.0 (0.0) 0.0 (0.0) 0.3 (0.1) 0.3 (0.1) 0.2 (0.1) 0.1 (0.1)
 Watery eyes 4.0 0.3 (0.1) 0.0 (0.0) 0.0 (0.0) 0.0 (0.0) 0.3 (0.1) 0.0 (0.0) 0.0 (0.0)
OOWS total 12.7 2.8 (0.4) 0.9 (0.2) 0.0 (0.0) 1.8 (0.4) 2.4 (0.4) 2.0 (0.2) 1.1 (0.2)
 Rhinorhea 3.2 0.4 (0.1) 0.0 (0.0) 0.0 (0.0) 0.2 (0.1) 0.1 (0.1) 0.3 (0.1) 0.0 (0.0)

Bolded F values indicate p<0.05. Bold mean (SE) values indicate significant (p<0.05) post-hoc compared to placebo. Only individual items with significant post-hoc result for dronabinol are shown. P.O. indicates oral route.