Figure 3.

Histologic appearance of porcine tissue after removal from the Ussing chamber. Tissue was treated with the bile salt, sodium deoxycholate. After 30min, epithelial loss is visible from the tips of villi. Epithelial losses continued for the first 45-min of recovery culminating in peak injury at time = 75-min. Between 75 and 210-min there was partial restitution of the injured villi by flattened to cuboidal migrating enterocytes. Uninjured control tissue maintained epithelial continuity throughout the study period. Magnification, 314X. Reproduced with permission.⁴⁹