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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: Nature. 2016 May 2;534(7605):47–54. doi: 10.1038/nature17676

Extended Data Figure 10. Signatures of focal hypermutation.

Extended Data Figure 10

(A) Kataegis and alternative kataegis occurring at the same locus (ERBB2 amplicon in PD13164a). Copy number (y-axis) depicted as black dots. Lines represent rearrangements breakpoints (green=tandem duplications, pink=deletions, blue=inversions). Topmost panel showing a ~10Mb region including the ERBB2 locus. Second panel from top zooms in 10-fold to a ~1Mb window highlighting co-occurrence of rearrangement breakpoints, with copy number changes and three different kataegis loci. Third panel from top demonstrates kataegis loci in more detail. Log10 intermutation distance on y axis. Black arrow highlighting kataegis. Blue arrows highlighting alternative kataegis.

(B) Sequence context of kataegis and alternative kataegis identified in this dataset.