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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: Nature. 2016 May 2;534(7605):47–54. doi: 10.1038/nature17676

Figure 5. Integrative analysis of rearrangement signatures.

Figure 5

Heatmap of rearrangement signatures (RS) following unsupervised hierarchical clustering based on proportions of RS in each cancer. 7 cluster groups (A-G) noted and relationships with expression (AIMS) subtype (basal=red, luminal B=light blue, luminal A=dark blue), immunohistopathology status (ER, PR, HER2 status – black=positive), abrogation of BRCA1 (purple) and BRCA2 (orange) (whether germline, somatic or through promoter hypermethylation), presence of 3 or more foci of kataegis (black=positive), HRD index (top 25% or lowest 25% - black=positive), GISTIC cluster group (black=positive) and driver mutations in cancer genes. miRNA cluster groups : 0=red, 1=purple, 2=blue, 3=light blue, 4=green, 5=orange. Contribution of base substitution signatures in these 7 cluster groups is provided in the lowermost panel.