Standard dosage	15 mg/kg in adults if administered daily and 25–30 mg/kg if administered twice or thrice weekly with a maximum dose of 1.5 g.
Contraindications	Hypersensitivity to the drug.
Major side effects	Vestibular ototoxicity, facial paresthesias, rash, fever, urticaria, angioneurotic edema, and eosinophilia.
Major drug interactions	Ototoxic effects accentuated with co-administration of ethacrynic acid, furosemide, mannitol and possibly other diuretics.
Special points	Category D drug in pregnancy.
Cost	Inexpensive.