Mechanism of action	It acts by binding to sterols in the fungus cell membrane, producing a change in membrane permeability that allows leakage of intracellular components from the cell.
Standard dosage	Cryptococcal meningitis: Amphotericin B: 0.7 to 1 mg/kg/day IV or lipid formulation amphotericin B 4–6 mg/kg IV daily plus flucytosine 100 mg/kg/day orally in 4 divided doses for 4 to 6 weeks (induction), followed by fluconazole 400 mg/day orally for 8 weeks (consolidation), then fluconazole 200 mg/day orally for 6 to 12 months (maintenance).
Major side effects	Hypotension, cardiac dysrhythmia, normochromic, normocytic anemia, agranulocytosis, nephrotoxicity, hypokalemia, thrombophlebitis. Dosages of 1.5 mg/kg/day can cause cardiac arrest.
Major drug interactions	Concomitant use of nephrotoxic medications or those with cardiac effects should be avoided or closely monitored.
Special points	It is the drug of choice for most CNS mycoses despite limited CNS penetration. Liposomal preparations have better penetration and lower toxicity. In select cases can be given intrathecally.