Standard dosage	Aspergillosis: initial loading dose 6 mg/kg IV every 12 h for 2 doses, followed by 4 mg/kg IV every 12 h; may switch to oral dosing with 200 mg every 12 h as tolerated. May require treatment for 1 year. CNS candidiasis: may treat initially with amphotericin B followed by oral voriconazole as maintenance therapy.
Contraindications	Concomitant use of carbamazepine, CYP3A4 substrates (terfenadine, astemizole, cisapride, pimozide, or quinidine), ergot alkaloids, long-acting barbiturates, rifabutin, rifampin, sirolimus, or St. John’s wort. Hypersensitivity to the drug.
Major side effects	Visual disturbance (21 %), hallucinations (2.4 % to 16.6 %), rash (7 %). Hepatitis, pancreatitis, toxic encephalopathy and prolonged QT interval are rare.
Major drug interactions	Drugs that induce liver enzymes can reduce plasma concentrations of voriconazole. Drugs with cardiac effects should be monitored closely. It may displace protein-bound drugs such as fosphenytoin to increase their concentration.
Special points	It is the drug of choice for aspergillosis.