Standard dosage	60 mg/kg/24 h as continuous infusion (adjusted for creatinine clearance) after 15 mg/kg loading dose aiming for serum levels of 15–25 mg/L.
Contraindications	Hypersensitivity to vancomycin.
Main drug interactions	Histamine-like reaction with concomitant anesthetic agents. Monitor carefully with neurotoxic or nephrotoxic drugs.
Main side effects	Overgrowth of non-susceptible organisms, nephrotoxicity, skin necrosis with inadvertent extravasation, thrombophlebitis, and reversible neutropenia.
Cost	Moderately expensive.