Table 1. Clinical Characteristics of PML Cases Following Transplantation from 4 Academic Medical Centers.

Case Number	Age/Sex	Underlying Diagnosis	Transplantation Type	Presenting Features	Time to PML Symptom Onset from Transplantation (mo)	Time to Diagnosis from Symptom Onset (mo)	Method of Diagnosis	Survival Following PML Diagnosis (mo)
1	42/F	Hepatitis C, alcohol abuse	Liver	HA, hand clumsiness, dysarthria	1	2	CSF	Still alive (155+)
2	50/M	Mantle cell lymphoma	Bone marrow	Irritability, memory loss, tremors	14	9	Suspected	34
3	56/F	Cryptogenic cirrhosis	Liver	Cortical blindness, seizures, hemiparesis	<1a	9	Autopsy	9
4	47/M	Histiocytosis X	Lung	Encephalopathy	63	1	Suspected	64
5	47/F	Amyloidosis	Heart	Cortical blindness	15	3	Brain biopsyb	13
6	64/M	Dilated cardiomyopathy	Heart	Encephalopathy	55	1	Suspected	43
7	39/F	Idiopathic pulmonary fibrosis	Lung	Ataxia	42	3	CSF	51
8	68/M	Cryptogenic cirrhosis	Liver	Hemiparesis	8	<1	CSF	9
9	56/F	Hepatitis C	Liver	Hemiparesis, hemianesthesia	116	8	CSF	124
10	68/M	Chronic lymphocytic leukemia transformed to B-cell lymphoma	Bone Marrow	Ataxia, aphasia	3	1	CSF, brain biopsy	5
11	55/M	Chronic membranous nephropathy	Kidney	Ataxia, dysarthria	32	2	CSF	34
12	62/F	Chronic obstructive pulmonary disease	Bilateral lung	Memory loss, ataxia, falls	27	<1	CSF	16
13	45/M	Hypertensive nephropathy	Kidney	Cognitive slowing, hemiparesis	202	1	CSF	204
14	43/M	Acute myeloid leukemia	Bone marrow	Diplopia	20	1	CSF	Still alive (44+)
15	40/M	Focal segmental glomerulosclerosis	Kidney	Monoparesis	48	12	CSF	Still alive (13+)

^aPatient was diagnosed with PRES in life; symptoms may have represented PRES or PML.

^bCSF PCR negative for JC virus in life.

CSF = cerebrospinal fluid; HA = headache; PCR = polymerase chain reaction; PML = progressive multifocal leukoencephalopathy; PRES = posterior reversible encephalopathy syndrome.