Table 2. Clinical Characteristics of Reported Cases of PML in Solid Organ Transplantation Recipients (January 1971–July 2010).
Author Last Name (Year of Publication) | Sex/Age at Transplantation | Underlying Disease Prompting Transplantation | Method of Diagnosis | Survival from Symptom Onset (mo)a | Attempted Treatment | |
---|---|---|---|---|---|---|
Lung (3) | ||||||
1 | Ouwens (2000)28 | 43/M | Bronchiectasis | CSF PCR | 20 | Y |
2 | Shitrit (2003)29 | 58/M | Idiopathic pulmonary fibrosis | Biopsy | NP | Y |
3 | Waggoner (2009)30 | 38/F | Idiopathic pulmonary fibrosis | CSF PCR | 5.25 | Y |
Heart (4) | ||||||
4 | Hall (1988)31 | 59/M | Ischemic cardiomyopathy | Autopsy | 0.75 | N |
5 | Flomenbaum (1991)32 | 49/M | Ischemic heart disease, Coronary artery disease | Autopsy | <1 | N |
6 | Lewis (1993)33 | 59/M | Ischemic heart disease | Biopsy | 15 | N |
7 | McCalmont (2007)34 | 68/M | Idiopathic cardiomyopathy | Autopsy | 0.5 | N |
Liver (6) | ||||||
8 | Worthmann (1994)35 | 53/F | Hepatitis C, cirrhosis | Autopsy | Asymptomatic | N |
9 | Bronster (1995)36 | 51/M | Cryptogenic cirrhosis | Biopsy | 2.25 | Y |
10 | Boulton-Jones (2001)37 | 60/F | Secondary biliary cirrhosis | CSF PCR | 22 | Y |
11 | Koralnik (2004)38 | 66/M | Nephrolithiasis | Biopsy | 4 | N |
12 | Lima (2005)39 | 39/F | Hepatitis C, cirrhosis | CSF PCR | 1.75 | Y |
13 | Alibert (2006)40 | 59/F | Hepatitis C, cirrhosis | CSF PCR | <6 | Y |
Kidney (19) | ||||||
14 | Manz (1971)4 | 33/F | Minimal glomerular change disease | Autopsy | 3.5 | N |
15 | ZuRhein (1974)41 | 34/M | Chronic glomerulonephritis | Autopsy | 2 | N |
16 | Legrain (1974)42 | 19/F | Chronic pyelonephritis | Autopsy | 6 | N |
17 | McCormick (1976)43 | 34/M | Chronic proliferative glomerulonephritis | Autopsy | 2.75 | N |
18 | Selhorst (1978)44 | 50/F | Not provided | Biopsy | 27+ | Y |
19 | Egan (1980)46 | 53/M | Chronic glomerulonephritis | Autopsy | 2.5 | N |
20 | Ho (1980)47 | 65/F | Radiation nephritis | Autopsy | 6 | N |
21 | Reznik (1981)A48 | 51/M | Hypertensive nephropathy | Autopsy | 13 | N |
22 | Reznik (1981)B48 | 45/F | Extramembranous glomerulonephrosis | Autopsy | 38 | N |
23 | Holzhausen (1984)49 | 44/M | Glomerulonephritis | Autopsy | 2 | N |
24 | Saxton (1984)50 | 28/M | Not stated | Biopsy | 13.5+ | Y |
25 | Garcia (1985)51 | 28/M | Chronic active glomerulonephritis | Biopsy | ∼5+ | Y |
26 | Embrey (1988)52 | 18/M | Obstructive nephropathy, solitary kidney | Biopsy | NP | Y |
27 | Táborský (1998)53 | 66/M | Chronic glomerulonephritis | CSF PCR | 5.25 | Y |
28 | Berner (1999)53 | 69/M | Chronic pyelonephritis | CSF PCR | 4 | N |
29 | Phillips (2004)54 | 16/M | ANCA-associated glomerulonephritis | CSF PCR | <1.25 | N |
30 | Crowder (2005)55 | 47/M | Alport syndrome | Biopsy | 37+ | Y |
31 | Manfro (2009)56 | 52/F | Chronic pyelonephritis | Biopsy | 4+ | Y |
32 | Epker (2009)57 | 50/M | Proliferative glomerulonephritis, diabetes mellitus | CSF PCR | 6+ | Y |
n = 32.
Case was reported before the time of death (censored at time of reporting; eg, 7+ equals survival last reported at 7 months).
ANCA = antineutrophil cytoplasmic antibody; CSF = cerebrospinal fluid; NP = not provided; PCR = polymerase chain reaction.