Table 3. Comparison of Solid Organ and Bone Marrow Transplant Recipients with Posttransplantation PML.
| Solid Organ Transplantation | Bone Marrow Transplantation | ||||||
|---|---|---|---|---|---|---|---|
| Current Series (n = 12) | Literature(n = 32) | Comparison of Current Series and Literature p Values | Combined(n = 44) | Current Series (n = 3) and Literature (n = 22) | Total (n = 69) | Combined Solid Organ vs Combined BMT Comparison | |
| Female, n (%) (95% CI) | 6 (50) | 11 (34) | 0.5482a | 17 (39) | 12 (48) | 26 (42) | 0.6145a |
| Mean age at transplantation, yr (95% CI) | 51.7 (45.6–57.8) | 47 (41.6–52.3) | 0.2292b | 48.3 (44.1–52.4) | 42.9 (38.0–47.8) | 46.3 (43.1–49.5) | 0.0912b |
| Range, yr | 39–68 | 16–69 | 16–69 | 14–68 | 14–69 | ||
| Number diagnosed at autopsy (%) | 1 (10) | 12 (38) | 0.1291c | 13 (30) | 3 (12) | 16 | 0.1728c |
| Median time from transplantation to first symptoms of PML, mo (95% CI) | 33.6 (15.2–60.7) | 27 (15–41.5) | 0.7046d | 27 (17.5–41.0) | 11 (6.7–16.7) | 17 (13.3–25.7) | 0.0005d |
| Range, mo | 0.2–198.8 | 1.5–245 | 0.2–245 | 1–78 | 0.2–245 | ||
| Median time from symptom onset to diagnosis of PML, mo (95% CI) | 1.7 (0.4–6.5) | 1.9 (1–3.5) | 0.5968d | 1.8 (1–2.9) | 0.9 (0.5–2.0) | 1.6 (1.0–2.2) | 0.1513d |
| Range, mo | 0.2–12.5 | 0.3–13.0 | 0.2–13.0 | 0.3–8.8 | 0.2–13 | ||
| Median time from symptom onset to death, mo (95% CI) | 8.0 (2.3, ∞) | 6 (4–22) | 0.956e | 6.4 (4.0–15.6) | 19.5 (7.0, ∞) | 8.4 (6.0–19.6) | 0.0679e |
| Range, mof | 0.85–152.6+ | 0.5–38+ | 0.5–152.6+ | 1.3–43.4+ | 0.5–152.6+ | ||
n = 69.
Two-sample proportions test with continuity correction.
t Test with unequal variances.
Two-sample proportions test with Yates continuity correction.
Two-sample Wilcoxon rank-sum (Mann-Whitney) test (p = 0.438 in 2-sample equality-of-medians chi-square test for median time from transplantation to symptom onset and 0.687 in symptom onset to diagnosis, p = 0.001 for difference between solid organ and BMT patients for median time to symptom onset of PML from transplantation).
Log-rank test.
The numbers written correspond to the observed follow-up times. The “+” indicates that some patients were censored (not observed until the time to death). BMT = bone marrow transplantation; CI = confidence interval; PML = progressive multifocal leukoencephalopathy.