Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 12.

Fig. 12

Effect of drug solubilizing agents on cocrystal and drug solubilities for DNZ and its cocrystals with HBA, and VAN, and for PTB and its cocrystals with CAF and with PIP. Tween 80 aqueous solution (150 mM, pH 5.0) used for danazol and lipid formulation for PTB (Captex 355/Capmul MCM (1/3): Cremophor EL (3:7)). Numbers represent cocrystal solubility advantage (SA= Scocrystal/Sdrug) in buffer with and without solubilizing agents. Both drugs are highly solubilized by the additives but their cocrystals are solubilized to a much lesser extent than drugs. Drug solubilizing agents decrease SA and can overturn it as in the case of PTB, where cocrystals become less soluble than PTB in the lipid formulation studied. Adapted with permission from M.P. Lipert and N. Rodríguez-Hornedo from ref. [70]. Copyright 2015 American Chemical Society.