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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 19.

Fig. 19

Cocrystal solubility advantage over drug or supersaturation index (SA) decreases in a predictable way with increasing (SRdrug). Full lines represent (1:1) cocrystals with SAaq = 2, 10, and 100. The dashed line indicates SA=1. The intersection of the cocrystal SA and SA=1 lines represents the SRdrug at which Scocrystal=Sdrug, and identifies transition points, which in these example are at SRdrug = 4, 100, and 10,000 for the corresponding cocrystals. Below the SRdrug limit, cocrystal is more soluble than drug but becomes less soluble than drug above this SRdrug value.