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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 2.

Fig. 2

Cocrystal solubility can be fine-tuned by (a) pH, (b) drug solubilizing agents, and (c) coformer concentration, where dashed line represents stoichiometric concentrations of (1:1) cocrystal. Solution conditions change the cocrystal solubility relative to drug solubility and so the cocrystal thermodynamic stability. The cocrystal is thermodynamically stable when Scocrystal ≤ Sdrug. The cocrystal solubility advantage over drug (Scocrystal/Sdrug) when Scocrystal > Sdrug is however critical to achieve higher drug concentrations during cocrystal dissolution.