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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 24.

Fig. 24

Dissolution methods may provide Cmax for moderately soluble cocrystals and may not detect highly soluble cocrystals. As cocrystals dissolve and drug precipitates, drug concentrations can reach a maximum in the case of moderately soluble cocrystals, whereas highly soluble cocrystals may undergo such rapid conversion that eludes detection and drug concentration is maintained close to or at the drug solubility. Adapted from ref.[66] with permission from The Royal Society of Chemistry.