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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 29.

Fig. 29

Concentrations of drug (carbamazepine, CBZ) and coformer (salicylic acid, SLC) at the eutectic point for the CBZ-SLC cocrystal and CBZ dihydrate system in water and in 1% SLS. In the absence of surfactant, [SLC]eu > [CBZ]eu, indicating that the cocrystal is more soluble than the drug. This situation is reversed in 1% SLS, where [CBZ]eu > [SLC]eu indicating that the cocrystal is less soluble than the drug. Solid phases at the eutectic point are the cocrystal and CBZ dihydrate, which is the drug solid form in equilibrium with cocrystal in aqueous media. Evaluation of Keu and Scc are described in the text.