Fig. 30.
Drug and coformer eutectic concentrations at different pH values for a) NVP-MLE, b) NVP-SAC and c) NVP-SLC. MLE cocrystal has higher coformer concentration at eutectic than the drug at all pH values. SAC and SLC cocrystal have a reversal in this trend as pH increase that indicate a pHmax. Reproduced from ref.[73] with permission from The Royal Society of Chemistry.