Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Fig. 31.

Fig. 31

Predicted and experimental values of Keu and cocrystal solubility advantage (Scocrystal/Sdrug) for 1:1 NVP-MLE and 2:1 NVP-SAC and NVP-SLC cocrystals. Keu is a key indicator of Scocrystal/Sdrug. Keu dependence on pH reveals the cocrystal pHmax as well as the cocrystal increase in solubility over drug as pH increases. At pHmax, Keu = 1 for 1:1 cocrystals and Keu = 0.5 for 2:1 cocrystals. Log axes are used due to the large range of values. Symbols represent experimental values. Numbers next to data points indicate pH at eutectic point or equilibrium pH. Lines were generated according to equations 20 and 21. Solid lines represent 1:1 cocrystals and dashed lines 2:1 cocrystals. Reproduced from ref.[73] with permission from The Royal Society of Chemistry.