. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Adv Drug Deliv Rev. 2016 Apr 29;101:143–166. doi: 10.1016/j.addr.2016.04.022

Table 4.

S* values for CBZ, DNZ, and PTB cocrystals in solutions with drug solubilizing agents, SLS, Tween, and lipid formulation.^a [70].

Cocrystal	pH	S*pred^b (mM)	S* obs^c (mM)
CBZ-SLC (1:1)	3.0	3.3	4.6
CBZ-SAC (1:1)	2.2	10.5	12.0
CBZ-4ABA-HYD (2:1)	4.0	21.8	22.0
CBZ-SUC (2:1)	3.1	48.0	47.6
DNZ-HBA (1:1)	5.0	90.0	>32
DNZ-VAN (1:1)	5.0	20.3	>17
PTB-CAF (1:1)	nr	58.6	<222
PTB-PIP (2:1)	nr	17.8	<246

Solubilizing agents are: aqueous solution of SLS for CBZ cocrystals, Tween 80 (150 mM, pH 5.0) for DNZ, and lipid formulation (Captex 355/Capmul MCM (1/3): Cremophor EL (3:7)) for PTB as described in the text.

S* predicted from equation 12 for 1:1 and 2:1 cocrystals.

Determined from the intersection of S_cocrystal,T and S_drug,T curves or measurement of cocrystal and drug solubilities in solubilizing agents.

After ref. [70].