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Key thermodynamic stability indicators for pharmaceutical solid-state forms
| Solid-state form | Thermodynamic parameter |
|---|---|
| Polymorphs | Transition temperature |
| Hydrates/anhydrous | Critical water activity or critical RH |
| Salts | pHmax |
| Amorphous | Tg, glass transition temperature |
| Cocrystals | Keu, or [coformer]eu and [drug]eu, pHmax, S* and CSC |
