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. 2016 Mar 30;17(5):546–557. doi: 10.1080/15384047.2016.1167292

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Figure 5. — The effect of Mitoxantrone on TRAIL resistant cell line, U373. (A) The effect of TRAIL (5–500 ng/ml) on intrinsically TRAIL resistant cells U373. (B) Effects of 0.02–20 μM of Mitoxantrone on U373 viability. (C) The effect as single agents and of the combination of the chosen dose of Mitoxantrone and TRAIL on U373 cells. (D) Caspase-8, −9 and −3/7 level detections of Mitoxantrone and/or TRAIL treated U373 cells. (E) The effect of caspase-8 or −9 inhibitors and general caspase inhibitors on U373 cells treated with Mitoxantrone, TRAIL and the combination. * indicates p <0.05 and ns indicates nonsignificant (p>0.05).