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. 2016 Mar 30;17(5):546–557. doi: 10.1080/15384047.2016.1167292

Table 1.

Top hits of U87MG and U87MG-R50 drug screens. Drugs that have significant effect on GBM cells as single agents are indicated in bold.

    U87MG Screen
U87MG-R50 Screen
Therapeutic class Drug Name Drug alone % cell viability ± SEM (% of control ) In combination with TRAIL % cell viability ± SEM (% of control) Drug alone % cell viability ± SEM (% of control ) In combination with TRAIL % cell viability ± SEM (% of control)
Antibacterial Doxorubicin hydrochloride 39 ± 8.1 13 ± 0.76 64 ± 4.1 12 ± 0.77
  Alexidine dihydrochloride 62 ± 5.1 6.4 ± 1.2    
  Monensin sodium salt 62 ± 8.8 24 ± 0.44 69 ± 2.3 37 ± 5.1
  Daunorubicin hydrochloride 65 ± 5.5 8.0 ± 0.76 58 ± 6.2 11 ± 1.3
  Methyl benzethonium chloride 72 ± 1.4 8.3 ± 2.7 76 ± 3.7 38 ± 22
  Cycloheximide 73 ± 5.9 3.2 ± 4.7 73 ± 10 12 ± 2.8
  Benzethonium chloride 77 ± 7.8 12 ± 4.4 89 ± 18 30 ± 12
  Amphotericin B 84 ± 5.5 21 ± 3.7    
 
Thiostrepton
 
 
84 ± 1.2
35 ± 4.4
Antineoplastic Camptothecine (S,+) 61 ± 6.1 5.1 ± 0.40 66 ± 4.9 8.1 ± 0.37
  Azacytidine-5 74 ± 5.5 17 ± 0.91    
  Vorinostat 75 ± 7.3 16 ± 2.7 81 ± 14 26 ± 0.10
  Topotecan 78 ± 4.5 9.3 ± 0.42 66 ± 7.3 14 ± 2.9
 
Mitoxantrone dihydrochloride
91 ± 1.8
1.7 ± 0.16
76 ± 1.8
3.1 ± 0.68
Cardiac glycosides Lanatoside C 31 ± 7.3 10 ± 2.1 37 ± 2.1 15 ± 0.37
  Digitoxigenin 44 ± 6.3 10 ± 3.2 41 ± 2.5 12 ± 2.3
  Proscillaridin A 42 ± 4.8 14 ± 2.2 38 ± 1.9 19 ± 1.4
  Digoxigenin 52 ± 2.6 6.9 ± 0.70 52 ± 4.7 11 ± 1.1
 
Digoxin
74 ± 7.9
13 ± 3.5
35 ± 1.7
13 ± 2.6
Immuno-suppressant
Cyclosporin A
84 ± 4.3
21 ± 1.2
 
 
Metabolism
Pyrvinium pamoate
52 ± 1.6
2.8 ± 0.28
56 ± 10
7.6 ± 1.7
Antihelmintic Niclosamide 41 ± 0.74 3.4 ± 0.21 70 ± 2.6 11 ± 3.6
 
Quinacrine dihydrochloride
61 ± 2.2
1.5 ± 0.37
60 ± 7.8
3.0 ± 0.77
Antihistaminic Terfenadine 62 ± 6.7 27 ± 2.8    
 
Astemizole
64 ± 3.4
26 ± 2.7
 
 
Antiseptic
Thonzonium bromide
67 ± 3.1
3.1 ± 0.81
62 ± 7.0
8.1 ± 4.2
Antispastic Pinaverium bromide 81 ± 0.97 27 ± 7.3    
Threshold for % cell viability 64% 29% 67% 40%