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Kinetic binding analysis of Octet. Affinity constant KD (M) for hertuzumab, trastuzumab and hertuzumab-vcMMAE binding to HER2-ECD was 5.02 × 10−10(circle), 1.86 × 10−9(up-pointing triangle), and 1.03 × 10−9(square), respectively. KD (M) of hertuzumab binding to trastuzumab saturated HER2-ECD was 1.80 × 10−9(down-pointing triangle). KD (M) of trastuzumab binding to hertuzumab saturated HER2-ECD was 6.96 × 10−9(rhombus). The data are summarized as mean ± SD of triplicate experiments
