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Cytotoxicity of Abs, ADCs and small molecule drugs on HER2-positive and negative gastric cancer cells in vitro.
| IC50 (ng/ml) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Hertuzumab-vcMMAEs |
||||||||
| Cell line | HER2 status | Hertuzumab-vcMMAE | Conjugated MMAE | Free MMAE | Hertuzumab | Trastuzumab- DM1 | Trastuzumab | Lapatinib |
| NCI-N87 | HER2+ | 95.3 | 1.9 | 7.7 | >10000 | 568.2 | >10000 | 75.6 |
| BGC-823 | HER2- | 6927.3 | 138.5 | 9.1 | >10000 | 8904.8 | >10000 | >1000 |
