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. 2016 Feb 6;17(4):346–354. doi: 10.1080/15384047.2016.1139248

Table 1.

Cytotoxicity of Abs, ADCs and small molecule drugs on HER2-positive and negative gastric cancer cells in vitro.

    IC50 (ng/ml)
    Hertuzumab-vcMMAEs
         
Cell line HER2 status Hertuzumab-vcMMAE Conjugated MMAE Free MMAE Hertuzumab Trastuzumab- DM1 Trastuzumab Lapatinib
NCI-N87 HER2+ 95.3 1.9 7.7 >10000 568.2 >10000 75.6
BGC-823 HER2- 6927.3 138.5 9.1 >10000 8904.8 >10000 >1000