Table 2.
Direct c-Jun target genes and described activities. The identified direct c-Jun target genes in malignant melanoma and their recently described cancer-relevant activities.
| Gene | Gene description | location |
|---|---|---|
| RRAS | related RAS viral (r-ras) oncogene homolog | 19q13.33 |
| PLEK2 | pleckstrin 2 | 14q23.3 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 β | 16q24.2 |
| WEE1 | WEE1 homolog (S. pombe) | 11p15.3-p15.1 |
| EPHA2 | EPH receptor A2 | 1p36 |
| ITGAV | integrin, α V | 2q31-q32 |
| DPP4 | dipeptidyl-peptidase 4 | 2q24.3 |
| PVR | poliovirus receptor | 19q13.2 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 14q22.3 |
| CLU | Clusterin | 8p21-p12 |
| ITPKA | inositol-trisphosphate 3-kinase A | 15q15.1 |
| NTN4 | NTN4 – netrin 4 | 12q22 |
| HPSE | heparanase | 4q21.3 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 17q21.32 |
| TOP1 | topoisomerase (DNA) I | 20q12-q13.1 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 7q22.1 |
| PRKCA | protein kinase C, α | 17q22-q23.2 |
| PDGFC | platelet derived growth factor C | 4q32 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2q33-q34 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 17q22-q23 |
| PPP1CB | protein phosphatase 1, catalytic subunit, β isozyme | 2p23 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 20q13.2 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 12p13 |
| CTNNAL1 | catenin (cadherin-associated protein), α-like 1 | 9q31.2 |
| PTK2 | protein tyrosine kinase 2 | 8q24.3 |
| PTPRH | protein tyrosine phosphatase, receptor type, H | 19q13.4 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 1q31 |
| CLDN16 | claudin 16 | 3q28 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 5p13.1 |
| PPL | Periplakin | 16p13.3 |
| DSTN | Destrin | 20p12.1 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 19q13.32 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 17p13.1 |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 11q13.5-q14.1 |
| PTGES | prostaglandin E synthase | 9q34.3 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 8p23.1 |
| ZAK | sterile α motif and leucine zipper containing kinase AZK | 2q24.2 |
| EZR | Ezrin | 6q25.3 |
| CD9 | CD9 molecule | 12p13.3 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 11p15.2 |
| SGCE | sarcoglycan, epsilon | 7q21.3 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 6q22.2-q22.3 |
| MAP1LC3A | microtubule-associated protein 1 light chain 3 α | 20q11.22 |
| OSBPL3 | oxysterol binding protein-like 3 | 7p15 |