Table 1.

Sequence information of each component of the complex.

	Amino Acids Sequence	Comment
3TAT-DRBD	GRKKRRQRRR GSH GRKKRRQRRR GSH GRKKRRQRRR GSHAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKA	TAT, 10 amino acids, triple TAT expressed in series GSH as linkers 16 (underlined)DRBD, motif 1 of human PKR,36 80 amino acids, residues from 9-78
SA	AEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHATFTKVKPSAA	natural core SA 39126 amino acids, residues from 21-130, 13.3 KDaD128A mutation (underlined)40
	Nucleic acids sequence	Comment
sur-siRNA	5′ GAAGCAGTTTGAAGAATTA dTdT 3′	Fluorescent siRNAs labeled with FAM or Cy7 at the 5′ end of the sense strand.
A10	5′biotin-GGGAGGA(fC)GA(fU)G(fC)GGA(fU)(fC)AG(fC)(fC)A(fU)G(fU)(fU)(fU)A(fC)G(fU)(fC)A(fC)(fU)(fC)(fC)(fU)(fU)3′5′Cy7-GGGAGGA(fC)GA(fU)G(fC)GGA(fU)(fC)AG(fC)(fC)A(fU)G(fU)(fU)(fU)A(fC)G(fU)(fC)A(fC)(fU)(fC)(fC)(fU)(fU)-biotin 3′	To increase stability against nuclease degradation, the pyrimidines in the aptamer A10 were 2′-fluoro modified.
A10-(sur-siRNA) chimera	5′GGGAGGA(fC)GA(fU)G(fC)GGA(fU)(fC)AG(fC)(fC)A(fU)G(fU)(fU)(fU)A(fC)G(fU)(fC)A(fC)(fU)(fC)(fC)(fU)(fU)-GAAGCAGUUUGAAGAAUUA 3′	A10-(sur-siRNA antisense strand ) chimera After a simple annealing, the 2 strands form stable chimera.22
	5′FAM/Cy7-UAAUUCUUCAAACUGCUUC dTdT 3′	sur-siRNA sense strand The 5′ end of the sense strand was labeled with FAM or Cy7.