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. 2015 Sep;10(17):2697–2708. doi: 10.2217/nnm.15.87

Figure 1. . Redox polymers derived from redox nanoparticles accumulated in the nonalcoholic steatohepatitis liver after disintegration of redox nanoparticles in the stomach.

Figure 1. 

(A) Scheme of redox polymer delivery from oral administration of RNP to liver. (B) Biodistribution of redox polymer in liver and kidney. (C) ESR measurement in liver. RNP (300 mg/kg) were administered to mouse for measurement of ESR in liver. (D) Fluorescence microscopy of liver section administered with 600 mg/kg rhodamine-RNP or RNP (no rhodamine) as a negative control. Scale bar: 100 μm. (E) Survival curve in mice fed with a CDAA diet administered with RNP and (F) bodyweight at beginning or termination of treatment in mice fed with a chow diet, fed with a CDAA diet administered with control (buffer), cNP, or RNP. Values are mean ±SEM.

*p < 0.05; **p < 0.01.

Bu: Buffer; CDAA: Choline deficient amino acid defined; cNP: Control nanoparticle; ESR: Electron spin resonance; RNP: Redox nanoparticle; SEM: Standard error of the mean.