Figure 4. . Dapivirine levels in vaginal lavages and genital tissues (vagina and lower half of the uterine horns) following vaginal administration of dapivirine-loaded poly(ethylene oxide)-modified polycaprolactone nanoparticles or the drug suspension in phosphate-buffered saline (dapivirine).

Note the different scales and units in y-axes, including the log-scale for vaginal lavages. Individual points represent mean values and vertical bars the standard error of the mean (n = 5). *p < 0.05 when comparing nanoparticles with free dapivirine at the same time point.

ND: Not detected; NP: Nanoparticle.

Reproduced with permission from [70] © Springer Science and Business Media (2014).