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. 2016 Mar 16;11(7):767–781. doi: 10.2217/nnm.16.14

Figure 1. . Whole body and ex vivo optical imaging of near-IR labeled chitosan/siMad2 nanoparticles in mice A549-WT tumor bearing mice for up to 96 h.

Figure 1. 

Prelabeled chitosan with a near-infrared Cy 5.5 dye was used to encapsulate siMad2 using a N:P ratio of 50:1. A549 tumor bearing mice were injected once in a concentration of 3 mg/kg of siMad2 encapsulated in nontargeted (NTG) or targeted (TG) CS nanoparticles. (A-B) Mice were imaged at different time points up to 96 h, on their posterior and lateral view using IVIS live imaging system. In these images we have two representative animals although a total of four animals per tumor model were used. A solution of free dye was also administered at equivalent concentration but it was only detected until 2 h after injection. Yellow arrow indicates tumor localization. (C) Ex vivo NIR images of major tissues excised from A549 tumor bearing mice at different time points post-injection.

NTG: Nontargeted; TG: Targeted; WT: Wild-type.