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Ratio (expressed in%) + SE of tumor exposure versus plasma exposure (A) or versus the sum of nontarget organs exposure (liver, kidney, spleen, heart, lung) for A549-WT and A549-DDP tumor models, after IV injection of NTG and TG nanoparticles at 3 mg/kg equivalent siRNA.
n = 5 mice.
*p < 0.05; **p < 0.01; ***p < 0.001 (t-test TG vs NTG).
DDP: Cisplatin; NTG: Nontargeted; SE: standard error; TG: Targeted.
