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. 2016 Jun 16;11(6):e0157376. doi: 10.1371/journal.pone.0157376

Fig 4. Omeprazole does not block Th2 cytokine-stimulated eotaxin-3 expression in esophageal fibroblasts.

Fig 4

(a) Treatment with omeprazole (OME) does not substantially decrease Th2 cytokine-induced eotaxin-3 mRNA expression at 48 hours in esophageal fibroblast cell lines FEE4-T and BEF-T when compared to esophageal epithelial cell line EoE2T. Graph depicts the fold change in eotaxin-3/GAPDH mRNA levels for the representative gels. (b) Treatment with omprazole does not significantly decrease protein secretion at 48 hours in esophageal fibroblast cell lines. (c) Omeprazole does not interfere with IL-4-induced STAT6 binding to the eotaxin-3 promoter in esophageal fibroblast cell lines. Densitometry values are normalized to loading control (GAPDH or Input Fraction). Data are the means ± SEM. NS, not significant.